Markakis has been a baseball lover from a very young age and a fan of the Boston Red Sox. He studied at Young Harris College, where he played on the college team Young Harris Mountain Lions.
In August 2003, he participated in the European Baseball Championship with the national team of Greece and won the silver medal. He also played with the Greek national team at the 2004 Olympic Games in Athens, Greece.
In 2004 he started his minor league career in the Delmarva Shorebirds team and in 2005 he went to the Maryland’s Frederick Keys team. He also participated in the All-Star game in California, in which he was voted Most Valuable Player (MVP). On April 3, 2006 Markakis started his major league career in the Orioles team and in 2009 he signed a 6-year contract for 66.1 million dollars. Moreover, in 2011 he received the Golden Glove award.
Markakis is married and has two children. In 2009, along with his wife Christine, they founded the Right Side Foundation in Maryland to support children in need. He also participates at various charity actions and campaigns and every year donates 75,000 dollars to their foundations.